Novel treatment of allergic fungal sinusitis using omalizumab
نویسندگان
چکیده
A case report of recalcitrant allergic fungal sinusitis (AFS) refractory to systemic corticosteroids and multiple functional endoscopic sinus surgeries (FESSs) treated with anti-IgE antibody omalizumab is reported. AFS is often classified with chronic rhinosinusitis (CRS). Although similar symptoms are among the two diseases, AFS has a unique pathophysiology. Patients with AFS demonstrate type 1 hypersensitivity to fungal allergens, increased total serum IgE, increased CD8(+) T-cell prevalence, and IL-4 and IL-5 response. Omalizumab should be considered in the treatment of AFS.
منابع مشابه
Diagnosis of Allergic Fungal Rhinosinusitis
Background: Allergic fungal sinusitis is a non-invasive disease, and accounts for approximately 6-8% of all chronic sinusitis requiring surgical intervention. As the treatment and prognosis of these disorders vary significantly, it is extremely important to recognize allergic fugal sinusitis and differentiate it from chronic sinusitis of bacterial and fungal origin. This prospective study evalu...
متن کاملALLERGIC FUNGAL SINUSITIS AMONG CANDIDATES FOR FUNCTIONAL ENDOSCOPIC SINUS SURGERY (FESS) IN SARI (IRAN)
Allergic fungal sinusitis (AFS) has been clinicopathologically defined as a noninvasive form of fungal infection. This study was designed to distinguish AFS among patients with chronic sinusitis who failed to respond to repeated courses of antibiotics and were therefore candidates for functional endoscopic sinus surgery (FESS) in Sari. Allergic mucin and sinus lavage was collected during F...
متن کاملPoster 1014: Omalizumab efficiency in patients with allergic rhinitis and chronic sinusitis
Background Allergic rhinitis (AR) is a very common chronic respiratory disorder and has also been shown to negatively impact quality of life with many comorbiliditys like Chronic rhinosinusitis; There is evidence that IgE antibodies play a role in chronic sinusitis. Investigations have shown that total IgE levels correlate with the severity of sinusitis, as assessed by CT scan. Allergies occur ...
متن کاملAllergic Fungal Sinusitis
Vol. 10 No. 1, January-March 2008 5 Introduction Allergic fungal sinusitis is a benign noninvasive sinus disease, believed to be an allergic reaction to aerosolized environmental fungi. It has been almost three decades when in 1976 Safirstein noted that the combination of polyposis, crust formation and sinus cultures yielding aspergillus was similar to the constellation of findings observed in ...
متن کاملRecent Progress in Allergen Immunotherapy
The efficacy of allergen immunotherapy for the treatment of allergic rhinoconjunctivitis with or without seasonal bronchial asthma and anaphylaxis caused by the sting of the hymenoptera class of insects has been clearly demonstrated in numerous well-designed, placebo-controlled trials. Immunotherapy whether by subcutaneous injection of allergen extract or by oral/sublingual routes modifies peri...
متن کامل